part of part of esophagus esophagus squamous epithelium non-keratinized stratified squamous epithelium stratum spinosum of esophageal epithelium 2024-11-14T15:00:21Z UBERON:8700002 The second deepest layer of the stratified squamous epithelium lining the esophagus, positioned directly above the stratum basale. It consists of multiple layers of keratinocytes connected by strong intercellular junctions called desmosomes, giving the cells a characteristic "spiny" appearance. This layer provides structural support, contributes to the epithelial barrier function, and serves as a transitional zone for keratinocytes migrating towards the luminal surface, playing a crucial role in maintaining the integrity and protective properties of the esophageal lining.