2-deoxy-D-ribose 1-phosphate degradation UPa:UPA00002 PMID:15205420 GO:0046386 This pathway provides a direct metabolic link between the deoxyribose moiety of nucleosides and central carbon metabolism, independent of the pentose phosphate cycle. Two enzymes provide this link: the phosphopentomutases (PPMs) and 2-deoxyribose 5-phosphate aldolases (DERAs). PPM isomerizes deoxyribose 1-phosphate to deoxyribose 5-phosphate. Subsequently, DERA cleaves the pentose phosphate to acetaldehyde and glyceraldehyde 3-phosphate, allowing further metabolism to obtain carbon and energy. The deoxyribose 1-phosphate is supplied by various nucleoside phosphorylases, such as thymidine phosphorylase, uridine phosphorylase and purine nucleoside phosphorylase, which release the pentose moiety from (deoxy)ribonucleosides, producing (deoxy)ribose 1-phosphate. PMID:9226884 pathway KEGG:map00030 carbohydrate degradation