L-lysine biosynthesis via DAP pathway MetaCyc:PWY-2941 MetaCyc:PWY-2942 L-lysine biosynthesis from aspartate UPa:UPA00034 PMID:12948639 L-lysine biosynthesis via diaminopimelate pathway pathway MetaCyc:DAPLYSINESYN-PWY KEGG:map00300 KEGG:map01100 KEGG:map01120 KEGG:map01110 PMID:11910040 GO:0009089 KEGG:map00260 PMID:17579770 KEGG:map00270 Biosynthesis of L-lysine through the diaminopimelate (DAP) pathway. <br> The L-lysine is synthesized from L-aspartate and pyruvate through diaminopimelate via four variants. <br> This pathway is utilised by most bacteria, some archaea, some fungi, some algae, and higher plants.<br> In bacteria, DAP is not only a direct precursor of lysine, but it is also an important constituent of the cell wall peptidoglycan. <br> The DAP pathway is of special interest for pharmacology, since the absence of DAP in mammalian cells allows for the use of the DAP biosynthetic genes as a bacteria-specific drug target. <br> Most bacteria use only one of the four variants, although certain bacteria, such as <i>C. glutamicum </i> and <i>Bacillus macerans</i>, possess both the succinylase and dehydrogenase pathways. MetaCyc:PWY-5097 PMID:9559056 amino-acid biosynthesis L-lysine biosynthesis