clavulanate biosynthesis PMID:16251194 KEGG:map01110 PMID:11988517 PMID:10422585 KEGG:map00331 Biosynthesis of clavulanic acid, a beta-lactam, structurally related to the penicillins, that possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. The name clavulanic acid is derived from the Streptomyces clavuligerus microorganisms from which clavulanic acid is derived. Clavulanic acid is biosynthetically generated from the amino-acid L-arginine and from pyruvate. pathway UPa:UPA00112 PMID:10869089 GO:0033050 beta-lactam biosynthesis antibiotic biosynthesis