hyaluronan metabolism hyaluronic acid metabolism Metabolism of hyaluronan (hyaluronic acid), a glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is one of the major components of the extracellular matrix and thereby contributes significantly to cell proliferation and migration. It may be involved in the progression of some malignant tumors. hyaluronate metabolism pathway UPa:UPA00519 GO:0030212 glycosaminoglycan metabolism