cofactor biosynthesis organic acid biosynthesis pteridine biosynthesis tetrahydrofolylpolyglutamate biosynthesis PMID:2688305 Biosynthesis of tetrahydrofolylpolyglutamates, a group of folate derivative compounds comprising tetrahydrofolate attached to a chain of glutamate residues. In organisms that require exogenous folates for growth (Lactobacillus casei, Streptococcus faecalis, mammals), highly anionic polyglutamate chain of folate (four glutamate residues or more) retard transport through the cell membrane. This is the mechanism thought to be responsible for the accumulation and maintenance of cellular folate pools. cell membrane. PMID:18232714 GO:0046901 pathway UPa:UPA00850