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    <!-- http://purl.obolibrary.org/obo/CHEBI_176497 -->

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        <oboInOwl:hasRelatedSynonym>1-methyltheobromine</oboInOwl:hasRelatedSynonym>
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        <oboInOwl:hasDbXref>PMID:18421070</oboInOwl:hasDbXref>
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        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
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        <oboInOwl:hasDbXref>PMID:11312039</oboInOwl:hasDbXref>
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        <oboInOwl:hasDbXref>PMID:8332255</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17132260</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>theine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasAlternativeId>CHEBI:3295</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>PMID:16709440</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11014293</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Caffeine</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>PMID:12915014</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:9218278</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11815511</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>LINCS:LSM-2026</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19007524</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17724925</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>1,3,7-trimethylxanthine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:23551936</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:18513215</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17508167</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>mateina</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:9132918</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15257305</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>1,3,7-Trimethylxanthine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:10803761</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:9067318</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Koffein</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>CAS:58-08-2</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:10510174</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:8679661</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:14607010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:10924888</oboInOwl:hasDbXref>
        <oboInOwl:hasAlternativeId>CHEBI:22982</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>PMID:11431501</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:12943586</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:10796597</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>cafeina</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:15280431</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>cafeine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:17932622</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17957400</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:12457274</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HMDB:HMDB0001847</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19879252</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Gmelin:103040</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:20164568</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:18647558</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>guaranine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:10822912</oboInOwl:hasDbXref>
        <oboInOwl:hasAlternativeId>CHEBI:41472</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>Drug_Central:463</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MetaCyc:1-3-7-TRIMETHYLXANTHINE</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DrugBank:DB00201</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Thein</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:15840517</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:27732</oboInOwl:id>
        <oboInOwl:hasRelatedSynonym>anhydrous caffeine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>Wikipedia:Caffeine</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:D00528</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:12574990</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.</ns4:IAO_0000115>
        <oboInOwl:hasExactSynonym>CAFFEINE</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>PMID:16644114</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:10884512</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>1,3,7-trimethyl-2,6-dioxopurine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Coffein</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:7689104</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>1,3,7-trimethylpurine-2,6-dione</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:19047957</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:18258404</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:8347173</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15681408</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19088793</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>teina</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:19418355</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19084078</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15718055</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24039592</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17387608</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:20470411</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:16856769</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:18625110</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22770225</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>methyltheobromine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:14521986</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>caffeine</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>PMID:18068204</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11209966</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22114686</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KNApSAcK:C00001492</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:9063686</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11949272</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:16391865</oboInOwl:hasDbXref>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35337 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35337">
        <rdfs:label>central nervous system stimulant</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35471 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35471">
        <rdfs:label>psychotropic drug</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35498 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35498">
        <rdfs:label>diuretic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35703 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35703">
        <rdfs:label>xenobiotic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50218 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50218">
        <rdfs:label>EC 3.1.4.* (phosphoric diester hydrolase) inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50925 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50925">
        <rdfs:label>EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_53121 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_53121">
        <rdfs:label>adenosine A2A receptor antagonist</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_60809 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_60809">
        <rdfs:label>adjuvant</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_64047 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64047">
        <rdfs:label>food additive</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_67114 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_67114">
        <rdfs:label>ryanodine receptor agonist</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_75771 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_75771">
        <rdfs:label>mouse metabolite</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_76924 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_76924">
        <rdfs:label>plant metabolite</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_76946 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_76946">
        <rdfs:label>fungal metabolite</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_78298 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78298">
        <rdfs:label>environmental contaminant</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_85234 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_85234">
        <rdfs:label>human blood serum metabolite</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



