has role 4-amino-1,2-oxazolidin-3-one metabolite organonitrogen heterocyclic antibiotic organooxygen heterocyclic antibiotic antitubercular agent antimetabolite D-cycloserine D-Cycloserine PMID:23656850 D-4-amino-3-isoxazolidinone chebi_ontology PA-94 Wikipedia:Cycloserine cyclo-D-serine PMID:5006234 PMID:12076471 PMID:22632472 Patent:US2840565 PMID:23523746 CAS:68-41-7 alpha-Cycloserine PMID:23438729 PMID:17707326 D-(+)-cycloserine PMID:23685206 PMID:22368237 DCS PMID:22234379 PMID:18316423 PMID:23416058 CHEBI:4030 Patent:US2772280 A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis). MetaCyc:CPD-2482 PMID:23542909 PDBeChem:4AX Ro-1-9213 PA 94 PMID:23174090 CHEBI:40009 HMDB:HMDB0014405 Drug_Central:759 (R)-4-AMINO-ISOXAZOLIDIN-3-ONE (+)-4-amino-3-isoxazolidinone orientomycin PMID:4555420 LIPID_MAPS_instance:LMPK14000007 KEGG:D00877 LINCS:LSM-5932 DrugBank:DB00260 (+)-cycloserine D-4-amino-3-isoxazolidone PMID:18930757 Reaxys:80798 PMID:22892161 PMID:18486041 NMDA receptor agonist D-cycloserine zwitterion L-cycloserine D-cycloserine(1+)