has role anticoronaviral agent geroprotector homodetic cyclic peptide metabolite immunosuppressive agent antifungal agent antirheumatic drug EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor cyclosporin A PMID:18975184 PMID:11870366 PMID:11442023 PMID:18259730 PMID:12050171 PMID:14521916 PMID:14621732 PMID:34561814 Patent:US4117118 PMID:16898534 PMID:11676831 PMID:19282398 PMID:14743390 Cyclosporine PMID:11278005 PMID:24134630 PMID:12761440 chebi_ontology PMID:17117422 PMID:11079273 MetaCyc:CPD-20532 PMID:12950728 PMID:15657176 PMID:17220244 VSDB:1765 PMID:16404634 Antibiotic S 7481F1 Wikipedia:Ciclosporin PMID:11557554 LIPID_MAPS_instance:LMPK14000003 PMID:15962181 PMID:12021257 PMID:17603747 PMID:11256490 PMID:15210365 PMID:18818682 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone Reaxys:3647785 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine] PMID:18597363 PMID:18790203 PMID:12929192 KEGG:D00184 PMID:17083576 KNApSAcK:C00001517 PMID:11406057 PMID:11058832 Drug_Central:760 Cyclosporin A PMID:15711594 PMID:19589783 Ciclosporin PMID:15811524 PMID:17446460 PMID:11529914 PMID:14638917 PMID:18217899 PMID:11564166 PMID:21752960 PMID:18076075 PMID:15626898 PMID:11426833 DrugBank:DB00091 PMID:12603598 KEGG:C05086 CAS:59865-13-3 PMID:11080188 PMID:18171316 PMID:11493684 cyclosporin A PMID:15541012 PMID:15613074 PMID:17229932 PMID:11481617 PMID:1566062 PMID:31144214 PMID:16724420 PMID:11315347 CHEBI:63586 PMID:18931077 PMID:16372476 PMID:23620378 PMID:11069928 HMDB:HMDB0250682 Chemspider:4447449 A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl) PMID:18583716 CHEBI:91802 PMID:11370709 PMID:18359899 PMID:15383526 PMID:15030555 PMID:17192032 PMID:34561200 PMID:18191430 CHEBI:4031 LINCS:LSM-1703 PMID:11238591 PMID:16801218 PMID:17265451 PMID:15175101 PMID:15306697 PMID:14672695 PMID:17032751 PMID:18299432 (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl) PMID:14682659 anti-asthmatic drug dermatologic drug carcinogenic agent