has role piperidines tertiary amine H1-receptor antagonist cyproheptadine Cyproheptadine Beilstein:1348386 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine 4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine LINCS:LSM-5419 The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia. PMID:10843226 DrugBank:DB00434 KEGG:C06935 CHEBI:111005 Drug_Central:765 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine 4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine CHEBI:605605 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine CYPROHEPTADINE CAS:129-03-3 Patent:US3014911 chebi_ontology CHEBI:4046 KEGG:D07765 cyproheptadine Wikipedia:Cyproheptadine serotonergic antagonist anti-allergic agent gastrointestinal drug antipruritic drug