<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/UPHENO?iri=http://purl.obolibrary.org/obo/CHEBI_59560"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:chebi="http://purl.obolibrary.org/obo/chebi#3"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_15372 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15372">
        <rdfs:label>5,6,7,8-tetrahydrobiopterin</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_33295 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33295">
        <rdfs:label>diagnostic agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_59560 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_59560">
        <rdfs:label>sapropterin</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15372"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33295"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasRelatedSynonym>6R-5,6,7,8-tetrahydrobiopterin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>tetrahydrobiopterin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>KEGG:C00272</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23266371</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Reaxys:4699705</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23712020</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23705856</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(6R)-L-erythro-tetrahydrobiopterin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:23235653</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CAS:17528-72-2</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Patent:EP191335</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:59560</oboInOwl:id>
        <oboInOwl:hasRelatedSynonym>(-)-(6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinone</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>6R-L-5,6,7,8-tetrahydrobiopterin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>CAS:27070-47-9</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:21466737</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Wikipedia:Sapropterin</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DrugBank:DB00360</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23430527</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23690520</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22575621</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22388642</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:4004257</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:16510994</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>R-THBP</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>MetaCyc:CPD-14053</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23436109</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22110560</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22832064</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22391997</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:D08505</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasDbXref>KNApSAcK:C00018229</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>5,6,7,8-Tetrahydrobiopterin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:22310224</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>6R-BH4</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:22112818</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Patent:US4713454</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23462988</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23743404</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:1297822</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HMDB:HMDB0000787</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Drug_Central:2612</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23430545</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PDBeChem:H4B</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>A tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1&#39;R,2&#39;S-enantiomer).</ns4:IAO_0000115>
        <oboInOwl:hasDbXref>PMID:21646032</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19627172</oboInOwl:hasDbXref>
        <oboInOwl:hasAlternativeId>CHEBI:64242</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>PMID:10333495</oboInOwl:hasDbXref>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



