<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/UPHENO?iri=http://purl.obolibrary.org/obo/CHEBI_7731"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:chebi="http://purl.obolibrary.org/obo/chebi#3"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000051 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000051">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label xml:lang="en">has part</rdfs:label>
        <rdfs:label>has_part</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_36047 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_36047">
        <rdfs:label>antibacterial drug</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_46577 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_46577">
        <rdfs:label>dextrofloxacin</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50750 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50750">
        <rdfs:label>EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_53559 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_53559">
        <rdfs:label>topoisomerase IV inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_59517 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_59517">
        <rdfs:label>DNA synthesis inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_60911 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_60911">
        <rdfs:label>racemate</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_63598 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63598">
        <rdfs:label>levofloxacin</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_7731 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_7731">
        <rdfs:label>ofloxacin</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_60911"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_86324"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_87211"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_46577"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36047"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_53559"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59517"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50750"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63598"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasDbXref>PMID:1804789</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Drug_Central:1981</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>DL 8280</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>OFLX</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:36228398</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HMDB:HMDB0015296</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:36004580</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11710934</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(+-)-ofloxacin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>racemic ofloxacin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>Wikipedia:Ofloxacin</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15008519</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:9228220</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>ORF 18489</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(3RS)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:3469159</oboInOwl:hasDbXref>
        <oboInOwl:hasAlternativeId>CHEBI:100146</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>MetaCyc:CPD-12843</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:36268299</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:7884650</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:C07321</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasDbXref>PMID:16669862</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DrugBank:DB01165</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:6960805</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>HOE-280</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>CHEBI:7731</oboInOwl:id>
        <oboInOwl:hasDbXref>PMID:12827054</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>LINCS:LSM-4370</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:35897550</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11903499</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>VSDB:1898</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19646516</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24550337</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:D00453</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:3546152</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>HOE 280</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>CAS:82419-36-1</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15557076</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>DL-8280</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>Reaxys:3657947</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.</ns4:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>rac-ofloxacin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:24497308</oboInOwl:hasDbXref>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_86324 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_86324">
        <rdfs:label>quinolone antibiotic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_87211 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_87211">
        <rdfs:label>fluoroquinolone antibiotic</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



