abnormal cell polarity FBcv:0000430 phenotypic_class cell polarity defective Phenotype that is any abnormality in the asymmetric distribution of components within a cell. For example an epithelial cell is 'cell polarity defective' if it lacks the normal asymmetric distribution of proteins or cell components such as junctions or villi along its apical-basal axis. phenotype abnormal cell polarity establishment or maintenance of cell polarity phenotype cell polarity variant