DNA topoisomerase activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity https://github.com/geneontology/go-ontology/issues/15575 https://github.com/geneontology/go-ontology/issues/17661 type II DNA topoisomerase activity DNA topoisomerase II DNA topoisomerase (ATP-hydrolysing) MetaCyc:5.99.1.3-RXN Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. DNA topoisomerase II activity deoxyribonucleate topoisomerase molecular_function Wikipedia:Type_II_topoisomerase GO:0061505 topoisomerase DNA topoisomerase IV activity topoisomerase II EC:5.6.2.2 deoxyribonucleic topoisomerase activity DNA topoisomerase type II activity GO:0003918 ATP-dependent activity, acting on DNA