has participant water hydron L-cysteine residue S-palmitoyl-L-cysteine residue hexadecanoate palmitoyl-(protein) hydrolase activity MetaCyc:3.1.2.22-RXN palmitoyl-[protein] hydrolase palmitoyl-protein thioesterase activity EC:3.1.2.22 Reactome:R-HSA-5690517 Reactome:R-HSA-203613 GO:0008474 Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. RHEA:19233 palmitoyl-protein hydrolase activity Reactome:R-HSA-9647994 palmitoyl-protein thiolesterase activity molecular_function Reactome:R-HSA-8933328 thiolester hydrolase activity palmitoyl hydrolase activity catalytic activity, acting on a protein