has participant fatty acid anion diphosphate(3-) adenosine 5'-monophosphate(2-) coenzyme A(4-) fatty acyl-CoA(4-) fatty acid ligase activity CoA-ligase activity fatty acid-CoA ligase activity https://github.com/geneontology/go-ontology/issues/28199 RHEA:38883 sjm MetaCyc:BUTYRATE--COA-LIGASE-RXN 2024-06-25T12:17:07Z GO:0120515 molecular_function Catalysis of the reaction: a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate.