tumor necrosis factor, TNF-like
tumor necrosis factor
PIRSF:PIRSF500467
Category=gene.
tumor necrosis factor ligand superfamily member 2
TNF
TNFA
TNF-alpha
protein
TNFSF2
cachectin
PR:000000134
TNFa
tumor necrosis factor alpha
TNF-a
A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells.