is_manufactured_by has function has role has component vaccinated in route immunizes against disease immunizes recipient immunizes against pathogen has drug brand name Human papillomavirus infectious disease Human papillomavirus Homo sapiens Gardasil vaccine Kallan Roan Oliver He http://purl.bioontology.org/ontology/RXNORM/659877 Quadrivalent vaccine meaning it protects against 4 strains of virus (types 6, 11, 16, and 18). The vaccine was made using genetic engineering techniques. The genes that encode a specific protein from each of these strains are expressed in yeast in large-scale fermentation cultures. Protein purification methods are then used to isolate the proteins and make the vaccine. Cited from: http://biotech.about.com/b/2008/09/03/gardasil-safety-of-genetically-engineered-hpv-vaccine-still-in-question.htm Gardasil vaccine - Prevention of vulvar and vaginal cancer - Vaccination in females 9 through 26 years of age for prevention of the following diseases caused by Human Papillomavirus (HPV) Types 6, 11, 16, and 18: - Cervical Cancer - Genital warts (condyloma acuminata) and the following precancerous or dysplastic lesions: - Cervical adenocarcinoma in situ (AIS)cancer - Cervical intraepithelial neoplasia (CIN) grade 2 and grade 3 - Vulvar intraepithelial neoplasia (VIN) grade 2 and grade 3 - Vaginal intraepithelial neoplasia (VaIN) grade 2 and grade 3 - Cervical intraepithelial neoplasia (CIN) grade 1 - Vaccination in boys and men 9 through 26 years of age for the prevention of genital warts caused by HPV types 6 and 11 - Vaccination in people ages 9 through 26 years for the prevention of anal cancer and associated precancerous lesions due to human papillomavirus (HPV) types 6, 11, 16, and 18 337 https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094042.htm 125126 https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=337 FDA licensed vaccine role intramuscular route USA licensed human vaccine preventive vaccine function prophylactic vaccine protein of pathogen organism as vaccine component recombinant vector vaccine multivalent vaccine recombinant vector vaccine role human papillomavirus vaccine Canada licensed human vaccine Canada licensed vaccine role L1 protein, Human papillomavirus type 6 Vaccine L1 protein, Human papillomavirus type 11 Vaccine L1 protein, Human papillomavirus type 18 Vaccine L1 protein, Human papillomavirus type 16 Vaccine vaccine multivalent role licensed human papillomavirus vaccine Merck & Co., Inc. Gardasil