has role immunizes against disease immunizes against pathogen test in lab animal model tularemia Mus musculus Francisella tularensis Francisella tularensis vaccine vaccine in research role sodB(Ft) vaccine 55 sodBFt is a live vaccine strain mutant of Francisella tularensis with reduced Fe-superoxide dismutase gene expression. Ref: PMID:18692537. sodB(Ft) Oliver He PMID:18692537 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=55 vaccine PMID:16923916 C57BL/6 mice were vaccinated intranasally (i.n.) with the sodB(Ft) mutant and challenged i.n. with lethal doses of F. tularensis SchuS4. SodB(Ft) vaccinated mice following SchuS4 challenge exhibited significantly reduced bacterial burden in lungs, liver and spleen, regulated production of pro-inflammatory cytokines and less severe histopathological lesions compared to the LVS vaccinated mice. The sodB(Ft) vaccination induced a potent humoral immune response and protection against SchuS4 required both CD4 and CD8 T cells in the vaccinated mice live attenuated bacterial vaccine live attenuated vaccine role