has role immunizes against pathogen test in lab animal model Mus musculus Bordetella bronchiseptica vaccine in research role Bordetella bronchiseptica vaccine Bordetella bronchiseptica aroA/trpE mutant vaccine Inactivation of the aroA gene highly attenuates B. bronchiseptica, severely impairing its ability to colonize and survive in the respiratory tract of mice. Upon challenge with wild type B. bronchiseptica, the mice immunised with live attenuated B. bronchiseptica aroA mutant had rapidly reduced numbers of B. bronchiseptica in their respiratory tract Oliver He 3268 Rebecca Racz vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=3268 A trpE mutant, in combination with an aroA mutation, is attenuated in mice and induces significant protection from challenge with wild type B. bronchiseptica