has function has role immunizes against disease immunizes recipient melanoma Homo sapiens melanoma vaccine recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role autologous TriMix-DC melanoma vaccine Gene name: MAGEC2 Gene name: MAGEA3 https://github.com/vaccineontology/VO/issues/286 Oliver He 970 4102 959 Gene name: CD40LG cancer vaccine 5238 7099 7299 Eliyas Asfaw Jie Zheng 6490 Gene name: CD70 A dendritic cell vaccine consisting of dendritic cells (DCs) electroporated with mRNA encoding three adjuvants, CD40 ligand (CD40L), a constitutively active TLR4, and CD70 (all together termed TriMix); coelectroporated with full-length mRNA encoding MAGE-A3, MAGE-C2, Tyrosinase and gp100; and linked to DC-LAMP, with potential immunostimulating activity. Upon vaccination, the DCs may stimulate the immune system to mount an antigen-specific cytotoxic T-lymphocyte (CTL) response against the melanoma antigens. This may decrease cellular proliferation of melanoma cells expressing these antigens. Electroporation with the adjuvants CD40L and TLR4 allows for the generation of mature and active DCs; electroporation with CD70 provides a costimulatory signal to CD27+ naive T cells thereby supporting T-cell proliferation and inhibiting T-cell apoptosis. Ibrahim Seleznev Gene name: gp100 (PMEL) 51438 Gene name: TLR4 Gene name: Tyrosinase VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5238 therapeutic cancer vaccine