is_manufactured_by immunizes against disease immunizes against pathogen malaria Plasmodium Plasmodium falciparum vaccine PfSPZ-Cvac vaccine https://www.ncbi.nlm.nih.gov/pubmed/28199305 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775905/ vaccine Randi Vita PfSPZ-Cvac The fully infectious PfSPZ are attenuated in vivo by concomitant administration of an anti-malarial drug (chloroquine). Chloroquine kills disease-associated blood stages but does not affect pre-erythrocytic (sporozoite or liver) stages, which are exposed to the host's immune system. Sporozoites-induced protection is mediated by immunity against pre-erythrocytic stages. https://www.ncbi.nlm.nih.gov/pubmed/26469720 PfSPZ Chemoprophylaxis Vaccine Oliver He Sanaria Inc., Rockville, MD