induces immune profile target receptor Toll-like receptor 7 1V270 vaccine adjuvant PMID:28724768 PMID:25568203 Chemical Nature: Small molecule Receptor: TLR7 Mechanism of Action: Activation of innate immune pathways Immune profile induced: Th1-biased Other Features/Characteristics: (1) Induces mucosal immunity, (2) Induces CD8 T cells, (3) Induces epitope spreading, (4) Provides innate protection, (5) Promotes antibody affinity maturation, (6) Promotes antibody epitope spreading By routes: intramuscular and intranasal. Point of Contact: Dennis Carson, UCSD 6 A vaccine adjuvant that includes IV270, which is a low-molecular weight TLR7 agonist conjugated to a phospholipid and is a highly potent and stable immune activator. VAC: https://vac.niaid.nih.gov/view?id=6 https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=114 PMID:32636840/ 1V270 Wolfgang Leitner vaccine adjuvant Oliver He Dennis Carson Th1-biased immune profile TLR7 agonist vaccine adjuvant