induces immune profile target receptor C-type lectin domain family 6 member A C-type lectin domain family 4 member E combination vaccine adjuvant Mannadjuvant Chemical Nature: (1) Natural compound, (2) Carbohydrate, (3) Combination adjuvant Receptor: CLR (Dectin, Mincle) and NAIP Mechanism of Action: Activation of Dectin-2-expressing innate immune cells; dual targeting of injection site and draining lymph node. Immune profile induced: Mixed Th1/Th2 Other Features/Characteristics: Promotes antibody epitope spreading Point of Contact: Ivan Zanoni, Boston Children's Hospital Amogh Madireddi VAC: https://vac.niaid.nih.gov/view?id=14 vaccine adjuvant Ivan Zanoni Wolfgang Leitner 14 https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=172 Oliver He Th1/Th2 mixed immune profile