induces immune profile target receptor Toll-like receptor 3 interferon-induced helicase C domain-containing protein 1 antiviral innate immune response receptor RIG-I defective viral genome-derived oligonucleotide vaccine adjuvant https://www.ncbi.nlm.nih.gov/pubmed/?term=29861183 Wolfgang Leitner 30 Defective viral genome-Derived Oligonucleotide Oliver He https://www.ncbi.nlm.nih.gov/pubmed/?term=24099876 DDO (Defective viral genome-Derived Oligonucleotide) DDO VAC: https://vac.niaid.nih.gov/view?id=30 https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=128 Chemical Nature: (1) Synthetic derivative of natural compound, (2) Nucleic acid Receptor: TLR3 Mechanism of Action: TLR3, possibly RIG-I - agonist Immune profile induced: Th1-biased Other Features/Characteristics: (1) Induces mucosal immunity, (2) Induces CD8 T cells, (3) Provides innate protection. By routes: SQ, IM. Point of Contact: Carolina Lopez, University of Washington at St Louis Carolina Lopez vaccine adjuvant Amogh Madireddi Th1-biased immune profile TLR3 agonist vaccine adjuvant oligonucleotide vaccine adjuvant