induces immune profile E. coli LT toxin derived vaccine adjuvant Th1/Th17 mixed immune profile dmLT vaccine adjuvant Oliver He https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=129 https://www.ncbi.nlm.nih.gov/pubmed/?term=23541621 https://www.ncbi.nlm.nih.gov/pubmed/?term=4927082 https://www.ncbi.nlm.nih.gov/pubmed/?term=25803825 https://www.ncbi.nlm.nih.gov/pubmed/?term=25111827 13 dmLT (double mutant of heat-labile E.coli) VAC: https://vac.niaid.nih.gov/view?id=13 https://www.ncbi.nlm.nih.gov/pubmed/?term=22202122 Elizabeth Norton Wolfgang Leitner https://www.ncbi.nlm.nih.gov/pubmed/?term=5461379 https://www.ncbi.nlm.nih.gov/pubmed/?term=21288994 https://www.ncbi.nlm.nih.gov/pubmed/?term=26018536 https://www.ncbi.nlm.nih.gov/pubmed/?term=26540197 https://www.ncbi.nlm.nih.gov/pubmed/?term=26305793 https://www.ncbi.nlm.nih.gov/pubmed/?term=6803349 vaccine adjuvant https://www.ncbi.nlm.nih.gov/pubmed/?term=3578125 double mutant of heat-labile E.coli https://www.ncbi.nlm.nih.gov/pubmed/?term=24453241 dmLT A vaccine adjuvant that includes double mutant of heat-labile E. coli toxin (LT) at R192G/L211A or LT(R192G/L211A) https://www.ncbi.nlm.nih.gov/pubmed/?term=19897067 https://www.ncbi.nlm.nih.gov/pubmed/?term=5216441 Chemical Nature: protein Mechanism of Action: CGM1 ganglioside, cAMP, inflammasome Immune profile induced: mixed Th1/Th17 Other Features/Characteristics: Induces mucosal immunity (IM, ID, SQ, SL, oral, , transcutaneous), Induces epitope spreading, Promotes antibody affinity maturation, Effective in newborns, promotes antibody epitope spreading By routes: IM, ID, SL, oral, SQ, IN, IP, intragastric, transcutaneous, transdermal, buccal, intrarectal Point of Contact: Elizabeth Norton, Tulane University https://www.ncbi.nlm.nih.gov/pubmed/?term=21288994 https://www.ncbi.nlm.nih.gov/pubmed/?term=6803349 https://www.ncbi.nlm.nih.gov/pubmed/?term=26540197 https://www.ncbi.nlm.nih.gov/pubmed/?term=4927082 https://www.ncbi.nlm.nih.gov/pubmed/?term=26305793 https://www.ncbi.nlm.nih.gov/pubmed/?term=25111827 https://www.ncbi.nlm.nih.gov/pubmed/?term=24453241 https://www.ncbi.nlm.nih.gov/pubmed/?term=22202122 https://www.ncbi.nlm.nih.gov/pubmed/?term=25803825 https://www.ncbi.nlm.nih.gov/pubmed/?term=23541621 https://www.ncbi.nlm.nih.gov/pubmed/?term=26018536 https://www.ncbi.nlm.nih.gov/pubmed/?term=5461379 https://www.ncbi.nlm.nih.gov/pubmed/?term=3578125 https://www.ncbi.nlm.nih.gov/pubmed/?term=5216441 https://www.ncbi.nlm.nih.gov/pubmed/?term=19897067 https://www.ncbi.nlm.nih.gov/pubmed/?term=25944298 https://www.ncbi.nlm.nih.gov/pubmed/?term=6424635 https://www.ncbi.nlm.nih.gov/pubmed/?term=3916310 https://www.ncbi.nlm.nih.gov/pubmed/?term=4826740 https://www.ncbi.nlm.nih.gov/pubmed/?term=2884428 https://www.ncbi.nlm.nih.gov/pubmed/?term=30778066 https://www.ncbi.nlm.nih.gov/pubmed/?term=4893257 https://www.ncbi.nlm.nih.gov/pubmed/?term=28063704 https://www.ncbi.nlm.nih.gov/pubmed/?term=4375349 https://www.ncbi.nlm.nih.gov/pubmed/?term=28792004 https://www.ncbi.nlm.nih.gov/pubmed/?term=25765967 https://www.ncbi.nlm.nih.gov/pubmed/?term=25483682 https://www.ncbi.nlm.nih.gov/pubmed/?term=30638799 https://www.ncbi.nlm.nih.gov/pubmed/?term=21326197 https://www.ncbi.nlm.nih.gov/pubmed/?term=31757774 https://www.ncbi.nlm.nih.gov/pubmed/?term=31427449 https://www.ncbi.nlm.nih.gov/pubmed/?term=6957164 https://www.ncbi.nlm.nih.gov/pubmed/?term=33465933 https://www.ncbi.nlm.nih.gov/pubmed/?term=33465933 https://www.ncbi.nlm.nih.gov/pubmed/?term=33465933 https://www.ncbi.nlm.nih.gov/pubmed/?term=31641151 https://www.ncbi.nlm.nih.gov/pubmed/?term=27133878 https://www.ncbi.nlm.nih.gov/pubmed/?term=27676456 https://www.ncbi.nlm.nih.gov/pubmed/?term=27226279 https://www.ncbi.nlm.nih.gov/pubmed/?term=22406456 https://www.ncbi.nlm.nih.gov/pubmed/?term=30787109 https://www.ncbi.nlm.nih.gov/pubmed/?term=24403527 https://www.ncbi.nlm.nih.gov/pubmed/?term=24403527 https://www.ncbi.nlm.nih.gov/pubmed/?term=30563789 https://www.ncbi.nlm.nih.gov/pubmed/?term=31757774 https://www.ncbi.nlm.nih.gov/pubmed/?term=30473185 https://www.ncbi.nlm.nih.gov/pubmed/?term=30248001 https://www.ncbi.nlm.nih.gov/pubmed/?term=24049109 https://www.ncbi.nlm.nih.gov/pubmed/?term=30797634 https://www.ncbi.nlm.nih.gov/pubmed/?term=31482013 https://www.ncbi.nlm.nih.gov/pubmed/?term=29771685 https://www.ncbi.nlm.nih.gov/pubmed/?term=31757774 https://www.ncbi.nlm.nih.gov/pubmed/?term=25444830 Clinical trials: https://clinicaltrials.gov/ct2/show/NCT03922061 https://clinicaltrials.gov/ct2/show/NCT04232943 https://clinicaltrials.gov/ct2/show/NCT02531685 https://clinicaltrials.gov/ct2/show/NCT02052934 https://clinicaltrials.gov/ct2/show/NCT02531802 https://clinicaltrials.gov/ct2/show/NCT01147445 https://clinicaltrials.gov/ct2/show/NCT03548064 https://clinicaltrials.gov/ct2/show/ NCT01739231 https://clinicaltrials.gov/ct2/show/NCT03404674 https://clinicaltrials.gov/ct2/show/NCT03729219 https://clinicaltrials.gov/ct2/show/NCT04826094