induces immune profile E. coli LT toxin derived vaccine adjuvant LTA1 vaccine adjuvant https://www.ncbi.nlm.nih.gov/pubmed/33986280 https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=171 LTA1 https://www.ncbi.nlm.nih.gov/pubmed/31641151 Wolfgang Leitner 44 https://www.ncbi.nlm.nih.gov/pubmed/22526674 Elizabeth Norton https://www.ncbi.nlm.nih.gov/pubmed/34516780 VAC: https://vac.niaid.nih.gov/view?id=44 https://www.ncbi.nlm.nih.gov/pubmed/31427449 https://www.ncbi.nlm.nih.gov/pubmed/26305793 https://www.ncbi.nlm.nih.gov/pubmed/6957164 Oliver He Ani M. Bernardi A vaccine adjuvant made from the A subunit of heat-labile (LT) enterotoxin of Enterotoxigenic Escherichia coli (ETEC). This LTA1 adjuvant is able to induce Th1, Th2, and Th17 immune responses. Chemical Nature: (1) Protein Mechanism of Action: cAMP, inflammasome induction Immune profile induced: mixed Th1/Th2/Th17 Other Features/Characteristics: (1) Induces mucosal immunity, (2) Induces epitope spreading, (3) Promotes antibody affinity maturation, (4) Promotes antibody epitope spreading, (5) High stability Route of immunization: IM, IN, SL, ID, IP Point of Contact: Elizabeth Norton, Tulane University vaccine adjuvant https://www.ncbi.nlm.nih.gov/pubmed/31929548 Th1/Th2/Th17 mixed immune profile