induces immune profile target receptor Toll-like receptor 3 interferon-induced helicase C domain-containing protein 1 antiviral innate immune response receptor RIG-I Th1/Th2 mixed immune profile PIKA vaccine adjuvant https://www.ncbi.nlm.nih.gov/pubmed/?term=26765968 Xiaoliang Ren Oliver He https://www.ncbi.nlm.nih.gov/pubmed/?term=21468931 https://www.ncbi.nlm.nih.gov/pubmed/?term=34766005 https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=183 https://www.ncbi.nlm.nih.gov/pubmed/?term=28118938 vaccine adjuvant PIKA https://www.ncbi.nlm.nih.gov/pubmed/?term=20538850 https://www.ncbi.nlm.nih.gov/pubmed/?term=29174316 VAC: https://vac.niaid.nih.gov/view?id=55 Chemical Nature: Nucleic Acid Mechanism of Action: TLR/RLR-agonist Immune profile induced: Th1/Th2 Route of immunization: IM and IN Point of Contact: Xiaoliang Ren, Yisheng Bio Ongoing clinical trial: https://clinicaltrials.gov/ct2/show/NCT02657161 https://clinicaltrials.gov/ct2/show/NCT02956421 https://www.ncbi.nlm.nih.gov/pubmed/?term=17484805 Wolfgang Leitner 55 TLR3 agonist vaccine adjuvant nucleic acid vaccine adjuvant