induces immune profile target receptor Toll-like receptor 7 Toll-like receptor 8 aluminum vaccine adjuvant Th1-biased immune profile 3M-052-Alum vaccine adjuvant VAC: https://vac.niaid.nih.gov/view?id=59 https://www.ncbi.nlm.nih.gov/pubmed/?term=34266981 https://www.ncbi.nlm.nih.gov/pubmed/?term=33971664 https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=141 https://www.ncbi.nlm.nih.gov/pubmed/?term=32561559 Wolfgang Leitner 59 https://www.ncbi.nlm.nih.gov/pubmed/?term=34117252 Christopher Fox Chemical Nature: small molecule Mechanism of Action: innate immune activation Immune profile induced: Th1-biased Route of immunization: IM Point of Contact: Christopher Fox, AAHI Clinical trials: https://clinicaltrials.gov/ct2/show/NCT04177355 https://clinicaltrials.gov/ct2/show/NCT04915768 https://clinicaltrials.gov/ct2/show/NCT05197712 vaccine adjuvant Oliver He https://www.ncbi.nlm.nih.gov/pubmed/?term=27847326 3M-052-Alum TLR7 agonist vaccine adjuvant TLR8 agonist vaccine adjuvant