induces immune profile target receptor Toll-like receptor 4 Th1-biased immune profile GLA-SE vaccine adjuvant https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=163 62 Wolfgang Leitner https://clinicaltrials.gov/ct2/show/NCT02071758 Christopher Fox Ani Bernardi https://clinicaltrials.gov/ct2/show/NCT01751048 https://www.ncbi.nlm.nih.gov/pubmed/?term=27142329 https://www.ncbi.nlm.nih.gov/pubmed/?term=21060869 vaccine adjuvant Ari Joffe Oliver He https://clinicaltrials.gov/ct2/show/NCT01484548 Chemical Nature: other Mechanism of Action: TLR4; Innate Immune Activation Immune profile induced: Th1-biased Route of immunization: IM Point of Contact: Christopher Fox, AAHI Pubmed References: https://www.ncbi.nlm.nih.gov/pubmed/?term=27142329 https://www.ncbi.nlm.nih.gov/pubmed/?term=21060869 https://www.ncbi.nlm.nih.gov/pubmed/?term=20944089 https://www.ncbi.nlm.nih.gov/pubmed/?term=20944089 https://www.ncbi.nlm.nih.gov/pubmed/?term=20944089 https://www.ncbi.nlm.nih.gov/pubmed/?term=21816196 https://www.ncbi.nlm.nih.gov/pubmed/?term=21690242 https://www.ncbi.nlm.nih.gov/pubmed/?term=21060869 https://www.ncbi.nlm.nih.gov/pubmed/?term=22291184 https://www.ncbi.nlm.nih.gov/pubmed/?term=22291184 https://www.ncbi.nlm.nih.gov/pubmed/?term=23045649 https://www.ncbi.nlm.nih.gov/pubmed/?term=23045649 https://www.ncbi.nlm.nih.gov/pubmed/?term=22509423 https://www.ncbi.nlm.nih.gov/pubmed/?term=22896687 https://www.ncbi.nlm.nih.gov/pubmed/?term=23904160 https://www.ncbi.nlm.nih.gov/pubmed/?term=23954378 https://www.ncbi.nlm.nih.gov/pubmed/?term=22425788 https://www.ncbi.nlm.nih.gov/pubmed/?term=22891286 https://www.ncbi.nlm.nih.gov/pubmed/?term=22891286 https://www.ncbi.nlm.nih.gov/pubmed/?term=23624057 https://www.ncbi.nlm.nih.gov/pubmed/?term=23624057 https://www.ncbi.nlm.nih.gov/pubmed/?term=23228811 https://www.ncbi.nlm.nih.gov/pubmed/?term=25024362 https://www.ncbi.nlm.nih.gov/pubmed/?term=25030053 https://www.ncbi.nlm.nih.gov/pubmed/?term=24404140 https://www.ncbi.nlm.nih.gov/pubmed/?term=24556505 https://www.ncbi.nlm.nih.gov/pubmed/?term=24556505 https://www.ncbi.nlm.nih.gov/pubmed/?term=24397898 https://www.ncbi.nlm.nih.gov/pubmed/?term=24397898 https://www.ncbi.nlm.nih.gov/pubmed/?term=24728521 https://www.ncbi.nlm.nih.gov/pubmed/?term=24728521 https://www.ncbi.nlm.nih.gov/pubmed/?term=25367751 https://www.ncbi.nlm.nih.gov/pubmed/?term=26541135 https://www.ncbi.nlm.nih.gov/pubmed/?term=25637347 https://www.ncbi.nlm.nih.gov/pubmed/?term=27005808 https://www.ncbi.nlm.nih.gov/pubmed/?term=26656121 https://www.ncbi.nlm.nih.gov/pubmed/?term=26874325 https://www.ncbi.nlm.nih.gov/pubmed/?term=26791076 https://www.ncbi.nlm.nih.gov/pubmed/?term=27466350 https://www.ncbi.nlm.nih.gov/pubmed/?term=27699241 https://www.ncbi.nlm.nih.gov/pubmed/?term=29176865 https://www.ncbi.nlm.nih.gov/pubmed/?term=27958370 https://www.ncbi.nlm.nih.gov/pubmed/?term=29263879 https://www.ncbi.nlm.nih.gov/pubmed/?term=29795025 https://www.ncbi.nlm.nih.gov/pubmed/?term=29983563 https://www.ncbi.nlm.nih.gov/pubmed/?term=29619252 https://www.ncbi.nlm.nih.gov/pubmed/?term=29619252 https://www.ncbi.nlm.nih.gov/pubmed/?term=27895131 https://www.ncbi.nlm.nih.gov/pubmed/?term=32636844 https://www.ncbi.nlm.nih.gov/pubmed/?term=29541075 https://www.ncbi.nlm.nih.gov/pubmed/?term=33705411 https://www.ncbi.nlm.nih.gov/pubmed/?term=35126135 https://www.ncbi.nlm.nih.gov/pubmed/?term=19679214 https://www.ncbi.nlm.nih.gov/pubmed/?term=26731269 https://www.ncbi.nlm.nih.gov/pubmed/?term=26453448 https://www.ncbi.nlm.nih.gov/pubmed/?term=26453448 https://www.ncbi.nlm.nih.gov/pubmed/?term=27456709 https://www.ncbi.nlm.nih.gov/pubmed/?term=32023469 https://www.ncbi.nlm.nih.gov/pubmed/?term=32402293 https://www.ncbi.nlm.nih.gov/pubmed/?term=32348377 https://www.ncbi.nlm.nih.gov/pubmed/?term=32697993 https://www.ncbi.nlm.nih.gov/pubmed/?term=29515589 https://www.ncbi.nlm.nih.gov/pubmed/?term=33046728 https://www.ncbi.nlm.nih.gov/pubmed/?term=31690678 https://www.ncbi.nlm.nih.gov/pubmed/?term=31174937 https://www.ncbi.nlm.nih.gov/pubmed/?term=30567978 https://www.ncbi.nlm.nih.gov/pubmed/?term=31362695 https://www.ncbi.nlm.nih.gov/pubmed/?term=29769270 https://www.ncbi.nlm.nih.gov/pubmed/?term=31521953 https://www.ncbi.nlm.nih.gov/pubmed/?term=28298421 Ongoing clinical trial: https://clinicaltrials.gov/ct2/show/NCT01484548 https://clinicaltrials.gov/ct2/show/NCT01751048 https://clinicaltrials.gov/ct2/show/NCT02071758 https://clinicaltrials.gov/ct2/show/NCT02465216 https://clinicaltrials.gov/ct2/show/NCT01927159 https://clinicaltrials.gov/ct2/show/NCT01599897 https://clinicaltrials.gov/ct2/show/NCT01154049 https://clinicaltrials.gov/ct2/show/NCT03302897 https://clinicaltrials.gov/ct2/show/NCT02465216 https://clinicaltrials.gov/ct2/show/NCT02508376 https://clinicaltrials.gov/ct2/show/NCT03806686 https://clinicaltrials.gov/ct2/show/NCT01949909 https://clinicaltrials.gov/ct2/show/NCT01540474 https://clinicaltrials.gov/ct2/show/NCT02014727 https://clinicaltrials.gov/ct2/show/NCT02647489 https://clinicaltrials.gov/ct2/show/NCT02658253 https://clinicaltrials.gov/ct2/show/NCT01991561 https://clinicaltrials.gov/ct2/show/NCT01596725 https://clinicaltrials.gov/ct2/show/NCT01147068 https://clinicaltrials.gov/ct2/show/NCT03820414 https://clinicaltrials.gov/ct2/show/NCT03220724 https://clinicaltrials.gov/ct2/show/NCT03409276 https://clinicaltrials.gov/ct2/show/NCT01864876 https://clinicaltrials.gov/ct2/show/NCT02115815 https://clinicaltrials.gov/ct2/show/NCT01397604 GLA-SE https://www.ncbi.nlm.nih.gov/pubmed/?term=20944089 VAC: https://vac.niaid.nih.gov/view?id=62 TLR4 agonist vaccine adjuvant