viral vaccine vector PVSRIPO vaccine vector A recombinant viral vaccine vector that uses PVSRIPO, a recombinant nonpathogenic polio-rhinovirus chimera. PVSRIPO is an engineerable oncolytic virus whereas its internal ribosomal entry site element can be substituted to demolish its cytopathogenic effect. PVSRIPO has a natural inherent tropism for antigen-presenting cells (including dendritic cells and macrophages) due to the presence of the CD-155 receptor on their cellular surfaces. This enables it of inducing CD8+ T-cell mediate immune responses. https://www.sciencedirect.com/science/article/pii/B978012810514600009X?via%3Dihub Oliver He https://link.springer.com/article/10.1007/s00109-008-0433-0 Mina Ashraf https://www.pnas.org/doi/full/10.1073/pnas.95.14.8216 vaccine component https://journals.aai.org/jimmunol/article/172/7/3994/71825/Cutting-Edge-CD96-Tactile-Promotes-NK-Cell-Target https://www.pnas.org/doi/abs/10.1073/pnas.93.6.2370 https://pubmed.ncbi.nlm.nih.gov/31988324/