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        <rdfs:label>induces immune profile</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/VO_0000366 -->

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        <rdfs:label>liposome-based vaccine adjuvant</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/VO_0005309 -->

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        <rdfs:label>Th1-biased immune profile</rdfs:label>
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        <rdfs:label>ME-F-1122 vaccine adjuvant</rdfs:label>
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        <ns3:IAO_0000119>VAC: https://vac.niaid.nih.gov/view?id=103</ns3:IAO_0000119>
        <ns3:IAO_0000119>Pubmed:27997339</ns3:IAO_0000119>
        <ns3:IAO_0000116>Chemical Nature: Natural compound - Liposome formulation with TLR4 agonist
Mechanism of Action: none
Immune profile induced: Mixed Th1/Th2

Route of immunization: SQ, Combination of sub-cheek, IN and ID, IN prime with sub-cheek boosts,
Point of Contact: Gary Fujii, Molecular Express

Pubmed References:
https://www.ncbi.nlm.nih.gov/pubmed/?term=23313243
https://www.ncbi.nlm.nih.gov/pubmed/?term=26312747
https://www.ncbi.nlm.nih.gov/pubmed/?term=27997339
https://www.ncbi.nlm.nih.gov/pubmed/?term=35680499
https://www.ncbi.nlm.nih.gov/pubmed/?term=19835825
https://www.ncbi.nlm.nih.gov/pubmed/?term=21545821
https://www.ncbi.nlm.nih.gov/pubmed/?term=16713037

Ongoing clinical trials:
none</ns3:IAO_0000116>
        <ns3:IAO_0000117>Jie Zheng</ns3:IAO_0000117>
        <ns3:IAO_0000119>Pubmed:21545821</ns3:IAO_0000119>
        <ns3:IAO_0000118>ME-F-1122</ns3:IAO_0000118>
        <ns3:IAO_0000117>Molecular Express</ns3:IAO_0000117>
        <ns3:IAO_0000119>Pubmed:23313243</ns3:IAO_0000119>
        <ns3:IAO_0000119>Pubmed:26312747</ns3:IAO_0000119>
        <ns3:IAO_0000117>Gary Fujii</ns3:IAO_0000117>
        <ns3:VO_0005328>103</ns3:VO_0005328>
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        <ns3:IAO_0000119>Pubmed:35680499</ns3:IAO_0000119>
        <ns3:IAO_0000119>Pubmed:16713037</ns3:IAO_0000119>
        <ns3:IAO_0000115>ME-F-1122 is a Liposome-based vaccine adjuvant with TLR4 agonist to induce a mixed Th1/Th2 response..</ns3:IAO_0000115>
        <ns3:IAO_0000233>https://github.com/vaccineontology/VO/issues/785</ns3:IAO_0000233>
        <ns3:IAO_0000119>Pubmed:19835825</ns3:IAO_0000119>
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