induces immune profile target receptor Toll-like receptor 9 CpG DNA vaccine adjuvant Th1-biased immune profile CpG 1018 vaccine adjuvant CpG 1018 ISS-1018 VAC: https://vac.niaid.nih.gov/view?id=105 105 Pubmed:39231203 Pubmed:38570604 Pubmed:35927132 Pubmed:35869085 Jie Zheng https://www.drugbank.ca/drugs/DB05463 vaccine adjuvant https://github.com/vaccineontology/VO/issues/787 Pubmed:24464743 ISS 1018 CpG oligodeoxynucleotide https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=473 Dynavax Short class B CpG-containing sequence with phosphorothioate-linked nucleotides that is able to induce a Th1-biased response. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/iss-1018-cpg-oligodeoxynucleotide Pubmed:33873199 Pubmed:37703367 Ben Wizel Pubmed:33649322 Chemical Nature: Nucleic acid Mechanism of Action: CpG 1018 is a short class B CpG-containing sequence with phosphorothioate-linked nucleotides Immune profile induced: Th1-biased Route of immunization: IN, IM Point of Contact: Ben Wizel, Dynavax Pubmed References: https://www.ncbi.nlm.nih.gov/pubmed/?term=24464743 https://www.ncbi.nlm.nih.gov/pubmed/?term=33649322 https://www.ncbi.nlm.nih.gov/pubmed/?term=33873199 https://www.ncbi.nlm.nih.gov/pubmed/?term=33888840 https://www.ncbi.nlm.nih.gov/pubmed/?term=38570604 https://www.ncbi.nlm.nih.gov/pubmed/?term=35927132 https://www.ncbi.nlm.nih.gov/pubmed/?term=35869085 https://www.ncbi.nlm.nih.gov/pubmed/?term=37703367 https://www.ncbi.nlm.nih.gov/pubmed/?term=39231203 Ongoing clinical trials: https://clinicaltrials.gov/ct2/show/ACTRN12624000064505 https://clinicaltrials.gov/ct2/show/NCT06334393 https://clinicaltrials.gov/ct2/show/NCT04177355 https://clinicaltrials.gov/ct2/show/NCT04672395 https://clinicaltrials.gov/ct2/show/NCT05188677 https://clinicaltrials.gov/ct2/show/NCT05011526 https://clinicaltrials.gov/ct2/show/NCT05364242 https://clinicaltrials.gov/ct2/show/NCT04956224 https://clinicaltrials.gov/ct2/show/NCT0486456 https://clinicaltrials.gov/ct2/show/ACTRN12620001177943 https://clinicaltrials.gov/ct2/show/NCT00251394 https://clinicaltrials.gov/ct2/show/NCT01282762 https://clinicaltrials.gov/ct2/show/NCT00346086 https://clinicaltrials.gov/ct2/show/NCT06569823 https://clinicaltrials.gov/ct2/show/NCT05245838 https://clinicaltrials.gov/ct2/show/NCT05506969 Pubmed:33888840 ISS 1018 CpG ODN