induces immune profile target receptor Toll-like receptor 3 C-type lectin domain family 4 member E combination vaccine adjuvant Th1-biased immune profile CAF24a vaccine adjuvant vaccine adjuvant A nanoemulsion engineered from the active components of CAF09 (dimethyldioctadecylammonium bromide, a synthetic monomycoloyl glycerol analog, and polyinosinic:polycytidylic acid), with a biodegradable squalane oil phase and varied surface charge by replacing DDA with zwitterionic distearoylphosphoethanolamine. CAF24a https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=351 PMID:29760705 Yuping Zheng TLR3 agonist vaccine adjuvant