induces immune profile target receptor Toll-like receptor 4 combination vaccine adjuvant Th1/Th2 mixed immune profile TLR4 agonist vaccine adjuvant ALFQ vaccine adjuvant Nilufer kosar ALFQ Mangala Rao Jie Zheng Oliver He VAC: https://vac.niaid.nih.gov/view?id=79 https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=146 79 Wolfgang Leitner vaccine adjuvant Chemical Nature: - Natural compound - Synthetic derivative of natural compound - Combination adjuvant Mechanism of Action: MPLA: TLR4 agonist QS21: Sugar-lawn likely recog. by lectins to facilitate uptake by M_, DCs, etc Immune profile induced: Mixed Th1/Th2 Route of immunization: ID, IM Point of Contact: Mangala Rao, Walter Reed Army Institute of Research Pubmed References: https://www.ncbi.nlm.nih.gov/pubmed/?term=34202178 https://www.ncbi.nlm.nih.gov/pubmed/?term=31827000 https://www.ncbi.nlm.nih.gov/pubmed/?term=34470866 https://www.ncbi.nlm.nih.gov/pubmed/?term=35632473 https://www.ncbi.nlm.nih.gov/pubmed/?term=36417525 https://www.ncbi.nlm.nih.gov/pubmed/?term=34914540 https://www.ncbi.nlm.nih.gov/pubmed/?term=32881968 https://www.ncbi.nlm.nih.gov/pubmed/?term=26372857 https://www.ncbi.nlm.nih.gov/pubmed/?term=36055874 https://www.ncbi.nlm.nih.gov/pubmed/?term=34202178 https://www.ncbi.nlm.nih.gov/pubmed/?term=36679887 https://www.ncbi.nlm.nih.gov/pubmed/?term=36934088 https://www.ncbi.nlm.nih.gov/pubmed/?term=34903722 https://www.ncbi.nlm.nih.gov/pubmed/?term=31775762 https://www.ncbi.nlm.nih.gov/pubmed/?term=28596090 https://www.ncbi.nlm.nih.gov/pubmed/?term=31151801 https://www.ncbi.nlm.nih.gov/pubmed/?term=34711815 https://www.ncbi.nlm.nih.gov/pubmed/?term=34159328 Ongoing clinical trials: https://clinicaltrials.gov/ct2/show/NCT04268420 https://clinicaltrials.gov/ct2/show/NCT04296279 https://clinicaltrials.gov/ct2/show/NCT04784767 https://clinicaltrials.gov/ct2/show/NCT05500417 https://clinicaltrials.gov/ct2/show/NCT04826094 https://clinicaltrials.gov/ct2/show/NCT04658667 https://clinicaltrials.gov/ct2/show/NCT05423418 A combination vaccine adjuvant that is an AS01-mimic, liposomal adjuvant of a TLR4 agonist and saponin. https://github.com/vaccineontology/VO/issues/633