induces immune profile target receptor Toll-like receptor 9 Th1-biased immune profile TLR9 agonist vaccine adjuvant oligonucleotide vaccine adjuvant S-540956 vaccine adjuvant 91 Chemical Nature: Oligonucleotide Mechanism of Action: Activation of TLR9 signaling pathway Immune profile induced: Th1-biased Route of immunization: IM, SQ Point of Contact: Maki Hayase, Shionogi &Co., Ltd Pubmed References: https://www.ncbi.nlm.nih.gov/pubmed/?term=35003132 https://www.ncbi.nlm.nih.gov/pubmed/?term=37243234 Ongoing clinical trials: N/A Maki Hayase vaccine adjuvant PMID:37243234 https://violinet.org/vaxjo/vaxjo_detail.php?c_vaxjo_id=190 An oligonucleotide vaccine adjuvant that is a TLR9-agonistic adjuant containing a CpG oligonucleotide annealed to a complementary strand with an amphiphilic chain unit, acts as a potent cancer vaccine adjuvant by targeting draining lymph nodes. Jie Zheng https://github.com/vaccineontology/VO/issues/667 Nilufer kosar PMID:35003132 S-540956 VAC: https://vac.niaid.nih.gov/view?id=91