has function has role immunizes against disease immunizes recipient test in lab animal model urinary bladder cancer Mus musculus Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role bladder cancer vaccine Recombinant Fowlpox GM-CSF Vaccine Adjuvant NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2686 cancer vaccine Jie Zheng PMID:15780740 1437 NCT: https://clinicaltrials.gov/ct2/show/NCT00072137 Gene name: GM-CSF VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=4994 Virginia He Oliver He Jimmy Guo A cancer vaccine adjuvant consisting of a recombinant fowlpox virus encoding human granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF binds to specific cell surface receptors on various immuno-hematopoietic cell types, enhancing their proliferation and differentiation and stimulating macrophage and dendritic cell functions in antigen presentation and antitumor cell-mediated immunity. Administration of recombinant fowlpox GM-CSF vaccine adjuvant may induce an immune response against tumor cells. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells. 4994 https://github.com/vaccineontology/VO/issues/328 therapeutic cancer vaccine