has function has role immunizes against disease immunizes recipient test in lab animal model brain cancer Mus musculus Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role brain cancer vaccine PF-04948568 Vaccine NCT: https://clinicaltrials.gov/ct2/show/NCT01498328 A cancer vaccine consisting of a human epidermal growth factor receptor variant III (EGFRvIIi)-specific peptide conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. Vaccination with rindopepimut may elicit a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing EGFRvIII. EGFRvIII, a functional variant of EGFR that is not expressed in normal tissues, was originally discovered in glioblastoma multiforme (GBM) and has also been found in various other cancers such as breast, ovarian, metastatic prostate, colorectal, and head and neck cancers. EGFRvIII contains an 83 amino acid deletion in its extracellular domain and has been shown to transform NIH/3T3 mouse embryonic fibroblast cells in vitro. https://github.com/vaccineontology/VO/issues/120 Oliver He 1956 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5032 Jie Zheng PMID:28844499 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C69076 Gene name: EGFR 5032 cancer vaccine Virginia He Jimmy Guo therapeutic cancer vaccine