has function has role immunizes against disease immunizes recipient brain cancer Homo sapiens therapeutic vaccine function DNA vaccine role vaccine in clinical trial role brain cancer vaccine VEGFR-2 DNA Vaccine VXM01 Virginia He PMID:29632710 Oliver He Jie Zheng NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C99378 5521 Gene name: KDR 3791 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5521 cancer vaccine NCT: https://clinicaltrials.gov/ct2/show/NCT02718443 Jimmy Guo An orally available DNA cancer vaccine containing an attenuated strain of the bacterium Salmonella typhimurium encoding murine vascular endothelial growth factor receptor 2 (VEGFR-2) (VXM01), with potential immunomodulating, anti-angiogenic and antineoplastic activity. Upon oral administration and successful transduction, VEGFR-2 DNA vaccine VXM01 expresses VEGFR-2 in addition to inducing the expression of T-cell activation markers, such as CD25, interleukin-2, the early T-cell activation antigen CD69 and the lymphocyte function-associated antigen LFA-2. The immune response targets the fast growing VEGFR-2 expressing endothelial cells found in the tumor vasculature, thereby blocking angiogenesis which may ultimately inhibit tumor cell proliferation. VEGFR-2 is a receptor tyrosine kinase overexpressed on proliferating endothelial cells in the tumor vasculature. therapeutic cancer vaccine DNA cancer vaccine