has function has role immunizes against disease immunizes recipient test in lab animal model prostate cancer urinary bladder cancer sarcoma lung non-small cell carcinoma esophageal cancer Mus musculus Homo sapiens therapeutic vaccine function DNA vaccine role vaccine in clinical trial role non-small cell lung cancer vaccine prostate cancer vaccine bladder cancer vaccine sarcoma cancer vaccine esophageal cancer vaccine NY-ESO-1 plasmid DNA cancer vaccine A plasmid DNA encoding an immunogenic peptide derived from the cancer-testis antigen NY-ESO-1 with potential immunostimulating and antitumor activities. Upon administration, NY-ESO-1 plasmid DNA cancer vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the NY-ESO-1 antigen, resulting in tumor cell lysis. NY-ESO-1 is a tumor associated antigen (TAA) found in normal testes and expressed on the surfaces of various tumor cells, including melanoma, breast, bladder, prostate, lung, ovarian, and hepatocellular tumor cells. Virginia He Gene name: CTAG1B Oliver He NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62452 5283 cancer vaccine Jimmy Guo https://github.com/vaccineontology/VO/issues/56 1485 https://github.com/vaccineontology/VO/issues/58 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5283 PMID:21900253 Jie Zheng NCT: https://clinicaltrials.gov/ct2/show/NCT00199849 PMID:15102697 therapeutic cancer vaccine DNA cancer vaccine