has function has role immunizes against disease immunizes recipient test in lab animal model sarcoma breast cancer melanoma ovarian cancer lung small cell carcinoma Mus musculus Homo sapiens melanoma vaccine therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role breast cancer vaccine lung cancer vaccine ovarian cancer vaccine sarcoma cancer vaccine NY-ESO-1/GLA-SE vaccine ID-G305AmN https://github.com/vaccineontology/VO/issues/85 1485 PMID:31069460 Oliver He Jie Zheng A cancer vaccine composed of a recombinant form of the tumor antigen NY-ESO-1 and glucopyranosyl lipid adjuvant (GLA)-stable emulsion (GLA-SE), with potential antineoplastic and immunomodulating activities. Upon intramuscular injection, the adjuvant portion of the NY-ESO-1/GLA-SE vaccine ID-G30 binds to toll-like receptor subtype 4 (TLR-4) expressed on dendritic cells (DCs), monocytes, macrophages and B cells. The activated DCs present the NY-ESO-1 antigen to Th1 CD4 T-lymphocytes. This leads to the induction of cytotoxic T lymphocytes (CTLs) and the killing of NY-ESO-1-expressing tumor cells. This vaccine also induces specific antibody responses and increases the production of inflammatory cytokines. NCT: https://clinicaltrials.gov/ct2/show/NCT02015416 7099 5445 Gene name: TLR4 Gene name: CTAG1B cancer vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5445 Jimmy Guo NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C113432 Virginia He therapeutic cancer vaccine