has function has role immunizes against disease immunizes recipient test in lab animal model sarcoma breast cancer pancreatic cancer Mus musculus Homo sapiens therapeutic vaccine function DNA vaccine role vaccine in clinical trial role pancreatic cancer vaccine breast cancer vaccine sarcoma cancer vaccine retrovector encoding mutant Anti-Cyclin G1 vaccine A replication-incompetent, pathotropic, tumor matrix (collagen)-targeted, retroviral vector encoding an N-terminal deletion mutant form of the cyclin G1 gene with potential antineoplastic activity. Under the control of a hybrid long-terminal repeat/cytomegalovirus (CMV) promoter, retrovector encoding mutant anti-cyclin G expresses the mutant cyclin G1 construct, resulting in disruption of tumor cell cyclin G1 activity and decreased cellular proliferation and angiogenesis. This agent preferentially targets collagen of the tumor matrix because of the incorporation of the collagen-binding domain of von Willebrand factor (vWF) on the retrovector surface. Exploiting the collagen-targeting mechanism of vWF permits delivery of the retrovector to tumor sites where angiogenesis and collagen matrix exposure occur. Oliver He Virginia He NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C49082 Jimmy Guo Jie Zheng VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5437 Gene name: CCNG1 https://github.com/vaccineontology/VO/issues/355 cancer vaccine 900 5437 NCT: https://clinicaltrials.gov/ct2/show/NCT00505271 therapeutic cancer vaccine DNA cancer vaccine