has function has role immunizes against disease immunizes recipient breast cancer melanoma Homo sapiens melanoma vaccine subunit vaccine therapeutic vaccine function subunit vaccine role vaccine in clinical trial role breast cancer vaccine survivin/p53/HER2 antigen-loaded autologous dendritic cell vaccine Gene name: p53 NCT: https://clinicaltrials.gov/ct2/show/NCT00978913 Gene name: Survivin 5180 PMID:16096014 Gene name: ERBB2 373110 Jie Zheng Oliver He Virginia He 7157 An autologous dendritic cell (DC) vaccine loaded with tumor-associated antigens (TAAs) derived from survivin, p53 and human epidermal growth factor receptor 2 (HER2 or ERBB2), with immunostimulating and antineoplastic activities. Upon administration, this DC vaccine may elicit a potent cytotoxic T-cell (CTL) response against tumor cells expressing these TAAs, resulting in tumor cell death. Survivin, p53 and HER2 are essential in neoplastic growth, and are considered to be universal tumor antigens. 2064 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C114285 cancer vaccine Jimmy Guo VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5180 therapeutic cancer vaccine