has function has role immunizes against disease immunizes recipient prostate cancer breast cancer ovarian cancer Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role prostate cancer vaccine breast cancer vaccine ovarian cancer vaccine therapeutic Breast/Ovarian/Prostate peptide cancer vaccine DPX-0907 Gene name: IGTB8 Gene name: TOP2A 780 5458 27 Gene name: JUP VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5458 A lipid-based multi-peptide cancer vaccine targeted against multiple cancers with immunopotentiating activity. Therapeutic breast/ovarian/prostate peptide cancer vaccine DPX-0907 is a lyophilized liposomal proprietary preparation comprised of 7 tumor-specific HLA-A2-restricted epitopes (TAAs): topoisomerase II alpha, B-cell receptor-associated protein 31 (CDM protein), TNF-alpha-converting enzyme (TACE/ADAM17), Abelson homolog 2 (Abl2), gamma catenin (Junction plakoglobin), epithelial discoidin domain receptor 1 (EDDR1) and integrin beta 8 subunit. Upon vaccination, the lyophilized antigen/adjuvant/liposome complex is re-suspended in Montanide 1SA51 VG to create a depot effect, thereby presenting the TAAs to the immune system for a prolonged period of time. This may stimulate a potent cytotoxic T-lymphocyte (CTL) immune response against cancer cells that express these 7 TAAs and share epitopes with the vaccine epitope peptides, resulting in tumor cell lysis. The 7 TAAs are overexpressed on the surface of breast/ovarian and prostate cancer cells and play an important role in tumor cell growth and survival. Oliver He Gene name: ABL2 Jie Zheng Virginia He 7153 PMID:22862954 Gene name: DDR1 10134 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C91077 3696 NCT: https://clinicaltrials.gov/ct2/show/NCT01095848 6868 Gene name: BCAP31 3728 Gene name: ADAM17 Jimmy Guo cancer vaccine therapeutic cancer vaccine