has function has role immunizes against disease immunizes recipient leukemia lung cancer breast cancer Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role breast cancer vaccine lung cancer vaccine leukemia cancer vaccine WT1 247-261 peptide vaccine Virginia He Gene name: WT1 5468 cancer vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5468 Jimmy Guo 7490 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104737 PMID:16220325 A synthetic peptide vaccine consisting of a HLA-DRw53-restricted human Wilms' Tumor protein-1 (WT1) peptide comprised of amino acids 247 through 261, a HLA class II-restricted WT1 peptide, with potential immunomodulating and antitumor activities. Vaccination with WT1 247-261 peptide may stimulate a CD4-positive helper T-lymphocyte-mediated immune response against WT1 expressing cells. Activated helper T-cells stimulate dendritic cells, and activate the proliferation of other T-lymphoctes and B-lymphocytes. This causes tumor cell lysis and inhibition of cancer cell proliferation in WT1-overexpressing tumor cells. WT1, a zinc finger DNA-binding protein, is overexpressed in most types of leukemia and in a variety of solid cancers. Jie Zheng Oliver He therapeutic cancer vaccine