has function has role immunizes against disease immunizes recipient test in lab animal model cervical cancer Mus musculus Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role cervical cancer vaccine Recombinant Vaccinia Viral Vector RO5217790 Vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5208 Oliver He Gene name: E7 NCT: https://clinicaltrials.gov/ct2/show/NCT01022346 https://github.com/vaccineontology/VO/issues/340 Gene name: E6 Jimmy Guo Virginia He 5208 Jie Zheng A cancer vaccine comprised of a modified, replication-defective, vaccinia virus Ankara (MVA) strain encoding the tumor-associated antigens (TAAs) human papillomavirus type 16 (HPV16) subtypes E6 and E7, and human interleukin-2 (IL-2), with potential immunostimulating and antineoplastic activities. Vaccination with MVA-HPV16E6/E7-IL2 vaccine TG4001 stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV16 E6 and E7, resulting in tumor cell lysis. Expression of IL-2 augments the specific CTL response against HPV16 E6- and E7-expressing tumor cells. cancer vaccine NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C88326 1489078 1489079 therapeutic cancer vaccine