has function has role immunizes against disease immunizes recipient test in lab animal model leukemia Mus musculus Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role leukemia cancer vaccine PR1 Leukemia Peptide Vaccine 5140 Oliver He VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5140 Virginia He NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2235 Gene name: TMEM37 140738 cancer vaccine NCT: https://clinicaltrials.gov/ct2/show/NCT00004918 A cancer vaccine containing PR1, a 9 amino-acid human leukocyte antigen (HLA)-A2 restricted peptide derived from proteinase 3, with potential immunotherapeutic activity. Vaccination with PR1 leukemia peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing proteinase 3, resulting in tumor cell lysis. Often overexpressed in leukemic cells, proteinase 3 is a serine proteinase that activates progelatinase A and is involved in angiogenesis and metastasis. Jimmy Guo PMID:27654852 Jie Zheng https://github.com/vaccineontology/VO/issues/139 therapeutic cancer vaccine