has function has role immunizes against disease immunizes recipient test in lab animal model liver cancer Mus musculus Homo sapiens therapeutic vaccine function vaccine in clinical trial role liver cancer vaccine Remestemcel-L Vaccine https://github.com/vaccineontology/VO/issues/353 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=4993 Jie Zheng Oliver He cancer vaccine PMID:32018062 Human mesenchymal stem cells (MSCs) harvested from bone marrow of healthy adult donors and expanded ex vivo, with potential immunosuppressive activity. Remestemcel-L cells are hypo-immunogenic due to lack of major histocompatibility II (MHC II) molecule expression, eliciting little, if any, host immune response upon intravenous infusion. Infusion of allogeneic MSCs may result in: a) increased production of anti-inflammatory cytokines, such as interleukin-10, prostaglandin E, and hepatocyte growth factor; b) decreased mononuclear phagocyte expression of indoleamine 2,3,-dioxygenase, which catabolizes L-tryptophan into its pro-inflammatory metabolites; and c) modulated dendritic cell (DC)maturation and disrupted activities of natural killer (NK) cells and CD8+ and CD4+ T cells. In addition, pluripotent MSCs, upon administration, may be recruited to damaged tissue sites, differentiating along specific lineages when stimulated. Virginia He NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C67082 Jimmy Guo 4993 therapeutic cancer vaccine