has function has role immunizes against disease immunizes recipient liver cancer Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role liver cancer vaccine Telomerase-specific Type 5 Adenovirus OBP-301 Vaccine PMID:27673332 Jimmy Guo cancer vaccine NCT: https://clinicaltrials.gov/ct2/show/NCT02293850 5072 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C119617 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5072 Virginia He Oliver He Jie Zheng Gene name: TERT 7015 A replication-competent oncolytic, telomerase-specific adenovirus serotype 5 (Ad5), with potential antineoplastic activity. OBP-301 contains the human telomerase reverse transcriptase (hTERT) gene promoter sequence that drives the expression of the E1A and E1B genes, and is linked to an internal ribosomal entry site (IRES). Upon administration, OBP-301 selectively infects and replicates in cancer cells that are expressing telomerase, which causes cell lysis. This adenovirus does not infect or replicate in normal, healthy cells. OBP-301 may also potentially be used as a chemosensitizer. hTERT, which encodes for the catalytic protein subunit of telomerase, is overexpressed in a variety of cancer cell types but not in normal, healthy cells. The insertion of an IRES further improves selectivity towards telomerase-expressing cancer cells. therapeutic cancer vaccine