has function has role immunizes against disease immunizes recipient test in lab animal model lung cancer Mus musculus Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role lung cancer vaccine Recombinant Adenovirus-L523S Vaccine 10643 A replication-defective adenovirus containing a gene that encodes the human protein L523S with potential antineoplastic activity. Upon administration, recombinant adenovirus-L523S vaccine expresses L523S, which may stimulate antibody and cytotoxic T lymphocyte (CTL) responses against tumor cells expressing L523S. L523S is an RNA-binding protein that belongs to the KOC (K homology domain containing protein over-expressed in cancer) family of proteins. As an oncofetal protein, L523S is normally expressed in early embryonic tissues and certain normal adult tissues such as colon, fallopian tube, gall bladder, and ovary tissues but may be overexpressed in squamous cell cancers of the lung. https://github.com/vaccineontology/VO/issues/323 Oliver He Jie Zheng VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5074 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C49289 Virginia He PMID:16581300 Jimmy Guo 5074 cancer vaccine NCT: https://clinicaltrials.gov/ct2/show/NCT00062907 Gene name: IGF2BP3 therapeutic cancer vaccine